PEMT Pre-design Chimera RNAi
产品名称： PEMT Pre-design Chimera RNAi
英文名称： PEMT Pre-design Chimera RNAi
产品编号： H00010400-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens phosphatidylethanolamine N-methyltransferase (PEMT), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_007169
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 10400
- Gene Name:
- PEMT
- Gene Alias:
- MGC2483,PEAMT,PEMPT,PEMT2,PNMT
- Gene Description:
- phosphatidylethanolamine N-methyltransferase
- Omim ID:
- 602391
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq
- Other Designations:
- OTTHUMP00000065536,OTTHUMP00000065537
- Gene Pathway
- Related Disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Choline Deficiency
- Cleft Lip
- Cleft Palate
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Edema
- Fatty Liver
- Fatty Liver, Alcoholic
- Folic Acid Deficiency
- Genetic Predisposition to Disease
- Metabolic Syndrome X
- Obesity
- Obesity, Abdominal
- Schizophrenia
- Schizophrenia
- Tobacco Use Disorder