SLCO2A1,溶质载体蛋白家族21成员2抗体

产品编号HZ-4710R
英文名称SLCO2A1
中文名称溶质载体蛋白家族21成员2抗体
别 名MATR1; Matrin F/G 1; OATP2A1; PGT; SO2A1_HUMAN; PHOAR2; Prostaglandin transporter; SLC21A2; Solute carrier family 21 (prostaglandin transporter) member 2; Solute carrier family 21 member 2; Solute carrier organic anion transporter family member 2A1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 通道蛋白 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
SLCO2A1,溶质载体蛋白家族21成员2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PGT/Slco2a1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SLCO2A1,溶质载体蛋白家族21成员2抗体PubMedPubMed
产品介绍background:
The organic anion transporting polypeptide (OATP) family of proteins play a role in drug absorption, distribution and excretion. OATP proteins mediate the uptake of a broad range of substrates, including bile salts, hormones, drugs and antibiotics, and they are expressed in various tissues, such as gut, brain, kidney and liver. PGT, also known as SLCO2A1 (solute carrier organic anion transporter family, member 2A1), SLC21A2 or OATP2A1, is a 643 amino acid multi-pass membrane protein that belongs to the organic anion transporter family. Expressed ubiquitously, PGT is thought to mediate the release, transepithelial transport and clearance of prostaglandins from cells to other areas of the body. The gene encoding PGT maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Function:
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain.

SLCO2A1,溶质载体蛋白家族21成员2抗体Database links:
Entrez Gene: 6578 Human
Omim: 601460 Human
SwissProt: Q92959 Human
Unigene: 518270 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.