ERAP2,内质网氨基肽酶2抗体

产品编号HZ-14658R
英文名称ERAP2
中文名称内质网氨基肽酶2抗体
别 名Endoplasmic reticulum aminopeptidase 2; L RAP; MUT7_HUMAN; Leukocyte derived arginine aminopeptidase; LRAP.
说 明 书0.1ml 0.2ml
研究领域细胞生物 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
ERAP2,内质网氨基肽酶2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量97kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ERAP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ERAP2,内质网氨基肽酶2抗体PubMedPubMed
产品介绍background:
Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]

Function:
ERAP2 is an aminopeptidase that plays a central role in peptide trimming. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP2 to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II. ERAP2 preferentially hydrolyzes the basic residues Arg and Lys.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Similarity:
Belongs to the mut-7 family.
Contains 1 3'-5' exonuclease domain.

Gene ID:
64167

ERAP2,内质网氨基肽酶2抗体Database links:
Entrez Gene: 64167 Human
Omim: 609497 Human
SwissProt: Q6P179 Human
Unigene: 482910 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.