HER2/ErbB2抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
HER2/ErbB2抗体

HER2/ErbB2抗体

商家询价

产品名称： HER2/ErbB2抗体

英文名称： HER2/ErbB2Antibody

产品编号： XY 51105-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 HER2/ERBB2抗体

Applications
Tested Applications: ELISA, WB, IF, IHC
Specificity Reaction: Human; Other species are not tested.Please decide the specificity by homology
Positive WB detected in HeLa cells, MCF7 cells
Positive IHC detected in Human breast cancer tissue, Breast Cancer slides
Positive IF detected in HeLa cells
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:20-1:200
 HER2/ERBB2抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev12NextView more validation data
  • 51105-1-AP;HeLa cellHeLa cells were subjected to SDS PAGE followed by western blot with 51105-1-AP(ERBB2 antibody) at dilution of 1:300
  • 51105-1-AP;human breast cancer tissueImmunohistochemical of paraffin-embedded human breast cancer using 51105-1-AP(ERBB2 antibody) at dilution of 1:50 (under 40x lens)
  • 51105-1-AP;human breast cancer tissueImmunohistochemical of paraffin-embedded human breast cancer using 51105-1-AP(ERBB2 antibody) at dilution of 1:50 (under 40x lens)
  • 51105-1-AP;human breast cancer tissueImmunohistochemical of paraffin-embedded human breast cancer using 51105-1-AP(ERBB2 antibody) at dilution of 1:50 (under 40x lens)
  • 51105-1-AP;HeLa cellsImmunofluorescent analysis of HeLa cells using 51105-1-AP( ERBB2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Product Information HER2/ERBB2抗体
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information
Immunogen: Peptide Full Name: V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Caculated Molecular
Weight:		 185 kDa Observed Molecular 
Weight:		 185 kDa
GenbankNo BC167147 GeneID: 2064
Symbol ERBB2 Synonyms CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1
Background

HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. HER2/ERBB2抗体

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