ACVR2A,激活素受体2A抗体

产品编号HZ-0804R
英文名称ACVR2A
中文名称激活素受体2A抗体
别 名Activin receptor 2A; Activin receptor type 2A; ACTR 2; ACTR IIA; ACTR2; ActRIIa; Acvr 2; Acvr 2A; Acvr2; Acvr2a; OTTHUMP00000197918; ACVR2A; Activin receptor type-2A.
规格价格0.1ml 0.2ml
说 明 书0.1ml 0.2ml
研究领域转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
ACVR2A,激活素受体2A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ACVR2A
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ACVR2A,激活素受体2A抗体PubMedPubMed
产品介绍background:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regulator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells and there is also evidence of expression of the gene in human brain and ovary.

Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Subunit:
Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.

ACVR2A,激活素受体2A抗体Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.

Gene ID:
92

Database links:
Entrez Gene: 92 Human
Entrez Gene: 11480 Mouse
Entrez Gene: 29263 Rat
Omim: 102581 Human
SwissProt: P27037 Human
SwissProt: P27038 Mouse
SwissProt: P38444 Rat
Unigene: 470174 Human
Unigene: 314338 Mouse
Unigene: 161783 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激活素受体ⅡA- ARIP2a属于ARIP家族新成员，在脑组织、垂体、睾丸中表达较高，胰腺、卵巢组织中有表达。