Collagen V,Ⅴ型胶原抗体

产品编号HZ-0552R
英文名称Collagen V
中文名称Ⅴ型胶原抗体
别 名Collagen Type V; AB collagen; Alpha 1 type V collagen; Alpha 2 type V collagen; Col5A1; Col5A2; COL5A2 protein; Col5A3; Collagen alpha 1(V) chain; Collagen alpha 2 (V) chain precursor; Collagen alpha 2(V) chain; Collagen alpha 3(V) chain; Collagen fetal membrane A polypeptide; Collagen type V alpha 1; Collagen type V alpha 2; Collagen type V alpha 3; Collagen V alpha 2 polypeptide; CollagenV; MGC105115; OTTHUMP00000064637; Pro alpha 1 type V collagen; Pro alpha 3(V) collagen; Procollagen alpha 2(V); Type V preprocollagen alpha 2 chain; collagen alpha-1(V) chain isoform 1 preproprotein.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
Collagen V,Ⅴ型胶原抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量153kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen V
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Collagen V,Ⅴ型胶原抗体PubMedPubMed
产品介绍background:
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

Function:
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

Subunit:
Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Post-translational modifications:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sulfated on 40% of tyrosines.

DISEASE:
Ehlers-Danlos syndrome 1 (EDS1) [MIM:130000]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.
Ehlers-Danlos syndrome 2 (EDS2) [MIM:130010]: Mild form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Collagen V,Ⅴ型胶原抗体Similarity:
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 laminin G-like domain.

Gene ID:
1289

Database links:
Entrez Gene: 1289 Human
Entrez Gene: 1290 Human
Entrez Gene: 50509 Human
Omim: 120190 Human
Omim: 120215 Human
Omim: 120216 Human
SwissProt: P05997 Human
SwissProt: P20908 Human
SwissProt: P25940 Human
SwissProt: Q15094 Human
SwissProt: Q53WR4 Human
SwissProt: Q5PR22 Human
SwissProt: Q5SY11 Human
SwissProt: Q86XF6 Human
Unigene: 210283 Human
Unigene: 235368 Human
Unigene: 445827 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.