SENP8 (C-term) Peptide
产品名称： SENP8 (C-term) Peptide
英文名称： SENP8 (C-term) Peptide
产品编号： P0324
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SENP8.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SENP8.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins.
Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT.J Biol Chem. 2003 Jul 11;278(28):25637-43. Epub 2003 May 1.
- 2.
- Identification and characterization of DEN1, a deneddylase of the ULP family.
Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD.J Biol Chem. 2003 Aug 1;278(31):28892-900. Epub 2003 May 19.
- 3.
- DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, Chen A, Lee CG, Wei N, Wilkinson KD, Wang R, Pan ZQ.J Biol Chem. 2003 Aug 1;278(31):28882-91. Epub 2003 May 19.
- Entrez GeneID:
- 123228
- Protein Accession#:
- NP_660205;Q96LD8
- Gene Name:
- SENP8
- Gene Alias:
- DEN1,HsT17512,NEDP1,PRSC2
- Gene Description:
- SUMO/sentrin specific peptidase family member 8
- Omim ID:
- 608659
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM
- Other Designations:
- NEDD8-specific protease 1,SUMO/sentrin specific protease family member 8,deneddylase 1,protease, cysteine, 2 (NEDD8 specific),sentrin/SUMO-specific protease SENP8