FITC标记的生长分化因子7抗体
产品名称： FITC标记的生长分化因子7抗体
英文名称： Anti-GDF7/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GDF7/FITC Conjugated antibody
FITC标记的生长分化因子7抗体
| 产品编号 | bs-11461R-FITC |
| 英文名称 | Anti-GDF7/FITC |
| 中文名称 | FITC标记的生长分化因子7抗体 |
| 别 名 | bmp12; bone morphogenetic protein 12; GDF-7; Gdf 7; GDF7_HUMAN; growth differentiation factor 7; Growth/differentiation factor 7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 干细胞 生长因子和激素 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDF7 (362-410aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1). Function: May play an active role in the motor area of the primate neocortex. Subunit: Homodimer; disulfide-linked Subcellular Location: Secreted. Similarity: Belongs to the TGF-beta family. Database links: UniProtKB/Swiss-Prot: Q7Z4P5.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
生长/分化因子（GDFs）是TGF超家族（1,2）的成员。TGF超家族成员参与胚胎发育和 组织稳态（1）。GDF-1表达几乎仅限于中枢神经系统，并介导胚胎发育过程中的细胞分化事件（3）。GDF -3（VGR-2）和GDF-9均不含在大多数其他TGF超家族成员中发现的保守半胱氨酸残基。GDF-3可在骨髓、脾脏、胸腺和脂肪组织中检测到，而GDF－9仅在卵巢（4）中检测到。GDF 5（也被指定为CDMP-1）已被诱导诱导纤溶酶原激活剂，从而诱导血管生成。它在胚胎发育过程中主要在长骨中表达，并参与骨形成。（5）。GDF -5突变已被证实为具有突变臂短臂（BP）的小鼠，该突变影响四肢骨的长度和数量（6）。GDF 6和GDF 7与GDF 5（6）密切相关。GDF－8已被证明是骨骼肌质量的负调节因子（1）。