DIMT1L,DIMT1L蛋白抗体

产品编号HZ-14331R
英文名称DIMT1L
中文名称DIMT1L蛋白抗体
别 名18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1 like; DIM1 dimethyladenosine transferase 1-like; Dimethyladenosine transferase; DIMT1; DIM1_HUMAN; DIMT1L; HSA9761; HUSSY5; N''-adenosyl(rRNA) dimethyltransferase; Probable 18S rRNA dimethylase; Probable dimethyladenosine transferase; S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase; S-adenosylmethionine-6-N''.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
DIMT1L,DIMT1L蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DIMT1L
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DIMT1L,DIMT1L蛋白抗体PubMedPubMed
产品介绍background:
DIMT1 is a 313 amino acid protein that belongs to the rRNA adenine N(6)-methyltransferase family. Localized to the nucleolus, DIMT1 functions to dimethylate adjacent adenosines on the conserved hairpin loop of 18S rRNA in the 40S particle. The gene encoding DIMT1 maps to chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

Subcellular Location:
Nucleus > nucleolus.

Similarity:
Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

Gene ID:
27292

Database links:
Entrez Gene: 27292 Human
GenBank: NM_014473 Human
SwissProt: Q9UNQ2 Human
Unigene: 726092 Human

DIMT1L,DIMT1L蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.