DOPA Decarboxylase,多巴胺脱羧酶抗体

产品编号HZ-0180R
英文名称DOPA Decarboxylase
中文名称多巴胺脱羧酶抗体
别 名AADC; DDC; Aromatic L Amino Acid Decarboxylase; DDC protein; DOPA decarboxylase; aromatic-L-amino-acid decarboxylase isoform 1; DDC_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
DOPA Decarboxylase,多巴胺脱羧酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DDC
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DOPA Decarboxylase,多巴胺脱羧酶抗体PubMedPubMed
产品介绍background:
DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.

Function:
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Subunit:
Homodimer.

DISEASE:
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.

Similarity:
Belongs to the group II decarboxylase family.

Gene ID:
1644

Database links:
Entrez Gene: 1644 Human
Entrez Gene: 13195 Mouse
Entrez Gene: 24311 Rat
Omim: 107930 Human
SwissProt: P20711 Human
SwissProt: O88533 Mouse
SwissProt: P14173 Rat
Unigene: 359698 Human
Unigene: 12906 Mouse
Unigene: 11064 Rat

DOPA Decarboxylase,多巴胺脱羧酶抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

该抗体主要用于：神经细胞退行性改变-老年滞呆的研究